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Genes Dev. 2007 Jan 15;21(2):143-7.

The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse.

Author information

1
Max-Planck-Institute for Molecular Genetics, Department of Developmental Genetics, Berlin 14195, Germany. herrmann@molgen.mpg.de

Abstract

Transmission ratio distortion (TRD), the preferential inheritance of the t haplotype from t/+ males, is caused by the cooperative effect of four t-complex distorters (Tcd1-4) and the single t-complex responder (Tcr) on sperm motility. Here we show that Fgd2, encoding a Rho guanine nucleotide exchange factor, maps to the Tcd2 region. The t allele of Fgd2 is overexpressed in testis compared with wild type. A loss-of-function allele of Fgd2 generated by gene targeting reduces the transmission ratio of the t haplotype t(h49), directly demonstrating the role of Fgd2 as Distorter. Fgd2 identifies a second Rho G protein signaling pathway promoting TRD.

PMID:
17234881
PMCID:
PMC1770897
DOI:
10.1101/gad.414807
[Indexed for MEDLINE]
Free PMC Article
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