Abstract
IFN-gamma is the most effective principle responsible for IDO induction in human cells in vitro. Lymphocyte factors support the effect of other IFN species. Induction of IDO and influence of various factors on IDO is correlated to pteridine synthesis. Cooperative effects of several mediators may account for in vivo observations concerning enhanced excretion of neopterin and tryptophan metabolites in certain disease states.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Biopterins / analogs & derivatives*
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Biopterins / metabolism
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Cells, Cultured
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Enzyme Induction / drug effects
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Fibroblasts / drug effects*
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Fibroblasts / enzymology
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Fibroblasts / metabolism
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Humans
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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Interferons / pharmacology*
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Leukocytes, Mononuclear / drug effects*
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Leukocytes, Mononuclear / enzymology
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Leukocytes, Mononuclear / metabolism
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Lipopolysaccharides
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Macrophages / drug effects*
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Macrophages / enzymology
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Macrophages / metabolism
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Neoplasm Proteins / biosynthesis
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Neoplasm Proteins / metabolism
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Neopterin
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Stimulation, Chemical
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Tryptophan / metabolism
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Tryptophan Oxygenase / biosynthesis*
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Tumor Cells, Cultured / drug effects*
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Tumor Cells, Cultured / enzymology
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Tumor Cells, Cultured / metabolism
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Tumor Necrosis Factor-alpha / pharmacology
Substances
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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Lipopolysaccharides
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Neoplasm Proteins
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Tumor Necrosis Factor-alpha
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Biopterins
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Neopterin
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Tryptophan
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Interferons
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Tryptophan Oxygenase