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Int J Clin Pract. 2007 Jan;61(1):105-18.

Non-nucleoside reverse transcriptase inhibitors: a review.

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1
Department of HIV/GU Medicine, Chelsea & Westminster Hospital, London, UK.

Abstract

Non-nucleoside reverse transcriptase inhibitors form the backbone of antiretroviral treatment for many HIV-infected individuals. The tolerability, pill burden and efficacy associated with this class of agents make them a frequent choice for first-line therapy. Here we review nevirapine and efavirenz in terms of efficacy, resistance and toxicity, focusing particularly on the use of nevirapine to prevent mother-to-child transmission in developing countries.

[Indexed for MEDLINE]

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