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Obesity (Silver Spring). 2007 Jan;15(1):245-52.

Burden of infection and fat mass in healthy middle-aged men.

Author information

1
Section of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomédica de Girona, Avinguda de França s/n, 17007 Girona, Spain. uden.jmfernandezreal@htrueta.scs.es

Abstract

OBJECTIVE:

Our aim was to study the effect of exposure to four infections on fat mass.

RESEARCH METHODS AND PROCEDURES:

This was a cross-sectional study of healthy middle-aged men from the general population (n = 74). Each study subject's serum was tested for specific IgG class antibodies against herpes simplex virus (HSV)-1, HSV-2, enteroviruses, and Chlamydia pneumoniae through the use of quantitative in vitro enzyme-linked immunosorbent assays (ELISAs). A total pathogen burden score based on these seropositivities [Quantitative Seropositivity Index (QSI)] was constructed. Fat mass was measured by bioelectrical impedance.

RESULTS:

We observed significant relationships between the HSV-1 titer and fat mass and percentage fat mass. The associations were stronger when considering the infection burden. The QSI was significantly associated with fat mass (r = 0.30, p = 0.009) and percentage fat mass (r = 0.27, p = 0.01). Those subjects in the highest tertile of fat mass showed significantly higher QSI (259.5 +/- 74.1 vs. 206.9 +/- 78.2, p = 0.007). In subjects that were seropositive for Enteroviruses, the relationship between the QSI and fat mass was strengthened (r = 0.51, p = 0.02). In a multivariate regression analysis, the QSI, independently of age and C-reactive protein, contributed to 9% of fat mass variance.

DISCUSSION:

Pathogen burden showed an association with fat mass. Subjects with increased fat mass could be more susceptible to developing multiple infections resulting in a chronic low-grade inflammation. We can not exclude the possibility that exposure to multiple infections leads to increased fat mass.

PMID:
17228053
DOI:
10.1038/oby.2007.541
[Indexed for MEDLINE]
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