Format

Send to

Choose Destination
J Pharm Pharmacol. 2007 Jan;59(1):3-13.

Targeting nitric oxide for cancer therapy.

Author information

1
School of Pharmacy, Queen's University Belfast, Belfast BT15 4DY, UK. D.Hirst@qub.ac.uk

Abstract

A blueprint for the ideal anticancer molecule would include most of the properties of nitric oxide (NO*), but the ability to exploit these characteristics in a therapeutic setting requires a detailed understanding of the biology and biochemistry of the molecule. These properties include the ability of NO* to affect tumour angiogenesis, metastasis, blood flow and immuno surveillance. Furthermore NO* also has the potential to enhance both radio- and chemotherapy. However, all of these strategies are dependent on achieving appropriate levels of NO*, since endogenous levels of NO* appear to have a clear role in tumour progression. This review aims to summarize the role of NO* in cancer with particular emphasis on how the properties of NO* can be exploited for therapy.

PMID:
17227615
DOI:
10.1211/jpp.59.1.0002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center