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Semin Cell Dev Biol. 2007 Feb;18(1):16-26. Epub 2006 Dec 20.

Ciona intestinalis as a model for cardiac development.

Author information

1
Department of Molecular and Cellular Biology, Division of Genetics & Development, University of California, Berkeley, CA 94720, United States. bandl@berkeley.edu

Abstract

The primitive chordate Ciona intestinalis has emerged as a significant model system for the study of heart development. The Ciona embryo employs a conserved heart gene network in the context of extremely low cell numbers and reduced genetic redundancy. Here, I review recent studies on the molecular genetics of Ciona cardiogenesis as well as classic work on heart anatomy and physiology. I also discuss the potential of employing Ciona to decipher a comprehensive chordate gene network and to determine how this network controls heart morphogenesis.

PMID:
17223594
PMCID:
PMC1857341
DOI:
10.1016/j.semcdb.2006.12.007
[Indexed for MEDLINE]
Free PMC Article
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