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Neuroimage. 2007 Mar;35(1):406-19. Epub 2007 Jan 12.

Sex differences in the development of neuroanatomical functional connectivity underlying intelligence found using Bayesian connectivity analysis.

Author information

1
Pediatric Brain Imaging Research Program, Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Vince.Schmithorst@cchmc.org <Vince.Schmithorst@cchmc.org>

Abstract

A Bayesian method for functional connectivity analysis was adapted to investigate between-group differences. This method was applied in a large cohort of almost 300 children to investigate differences in boys and girls in the relationship between intelligence and functional connectivity for the task of narrative comprehension. For boys, a greater association was shown between intelligence and the functional connectivity linking Broca's area to auditory processing areas, including Wernicke's areas and the right posterior superior temporal gyrus. For girls, a greater association was shown between intelligence and the functional connectivity linking the left posterior superior temporal gyrus to Wernicke's areas bilaterally. A developmental effect was also seen, with girls displaying a positive correlation with age in the association between intelligence and the functional connectivity linking the right posterior superior temporal gyrus to Wernicke's areas bilaterally. Our results demonstrate a sexual dimorphism in the relationship of functional connectivity to intelligence in children and an increasing reliance on inter-hemispheric connectivity in girls with age.

PMID:
17223578
PMCID:
PMC2100392
DOI:
10.1016/j.neuroimage.2006.11.046
[Indexed for MEDLINE]
Free PMC Article

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