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Mol Cell Neurosci. 2007 Mar;34(3):281-7. Epub 2007 Jan 12.

Thinking within the D box: initial identification of Cdh1-APC substrates in the nervous system.

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Department of Pathology, Harvard Medical School, New Research Building, 77 Ave Louis Pasteur, Room 856, Boston, MA 02115, USA.


The anaphase-promoting complex (APC) has a well-established role in cell cycle control, but recent exciting evidence has uncovered unexpected neurobiological functions for this complex E3 ubiquitin ligase. With its co-activator Cdh1, APC's effects upon the nervous system range from regulation of axon growth and patterning to development of synapses to neuronal survival. The Cdh1-APC substrates that control these biological processes in neurons are just beginning to be identified. These findings may offer a glimpse of the wide spectrum of neural activities that are orchestrated by Cdh1-APC.

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