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J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):793-8. Epub 2007 Jan 12.

Vitamin D in the treatment of pulmonary tuberculosis.

Author information

1
Centre for Health Sciences, Institute of Health Sciences Education, Barts and The London School of Medicine and Dentistry, London E1 2AT, United Kingdom. a.martineau@qmul.ac.uk

Abstract

Vitamin D was used to treat tuberculosis in the pre-antibiotic era. New insights into the immunomodulatory properties of 1alpha,25-dihydroxy-vitamin D have rekindled interest in vitamin D as an adjunct to antituberculous therapy. We describe the historical use of vitamin D in tuberculosis treatment; discuss the mechanisms by which it may modulate host response to infection with Mycobacterium tuberculosis; and review three clinical trials and ten case series in which vitamin D has been used in the treatment of pulmonary tuberculosis.

PMID:
17223549
DOI:
10.1016/j.jsbmb.2006.12.052
[Indexed for MEDLINE]

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