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Curr Opin Neurobiol. 2007 Feb;17(1):120-7. Epub 2007 Jan 12.

The role of extracellular matrix in CNS regeneration.

Author information

1
Case Western Reserve University School of Medicine, Department of Neurosciences, 2109 Adelbert Road E-658, Cleveland, Ohio 44106, USA.

Abstract

Chondroitin sulfate proteoglycans are the principal inhibitory component of glial scars, which form after damage to the adult central nervous system and act as a barrier to regenerating axons. Recent findings have furthered our understanding of the mechanisms that result in a failure of regeneration after spinal cord injury and suggest that a multipartite approach will be required to facilitate long-distance regeneration and functional recovery.

PMID:
17223033
DOI:
10.1016/j.conb.2006.09.004
[Indexed for MEDLINE]

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