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Neurobiol Aging. 2008 May;29(5):789-92. Epub 2007 Jan 11.

BDNF genotype potentially modifying the association between incident stroke and depression.

Author information

1
Department of Psychiatry and Depression Clinical Research Center, Chonnam National University Medical School, Kwangju, Republic of Korea.

Abstract

OBJECTIVE:

To investigate the role of the brain-derived neurotrophic factor (BDNF) gene val66met polymorphism in the association between stroke and depression.

METHOD:

Five hundred community residents aged >65 years without stroke or depression at baseline were re-evaluated after 2 years. Disability (World Health Organization Disability Assessment Schedule, WHODAS II), cognitive function (Mini-Mental State Examination, MMSE), and BDNF genotype were also measured at baseline.

RESULTS:

The association between incident stroke and depression was strengthened progressively with increasing numbers of met alleles, and was only significant in subjects with the met/met genotype after adjustment for disability and cognitive function.

CONCLUSION:

The BDNF val66met polymorphism may modify the association between stroke and depression.

[Indexed for MEDLINE]

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