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Neurobiol Aging. 2008 May;29(5):789-92. Epub 2007 Jan 11.

BDNF genotype potentially modifying the association between incident stroke and depression.

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Department of Psychiatry and Depression Clinical Research Center, Chonnam National University Medical School, Kwangju, Republic of Korea.



To investigate the role of the brain-derived neurotrophic factor (BDNF) gene val66met polymorphism in the association between stroke and depression.


Five hundred community residents aged >65 years without stroke or depression at baseline were re-evaluated after 2 years. Disability (World Health Organization Disability Assessment Schedule, WHODAS II), cognitive function (Mini-Mental State Examination, MMSE), and BDNF genotype were also measured at baseline.


The association between incident stroke and depression was strengthened progressively with increasing numbers of met alleles, and was only significant in subjects with the met/met genotype after adjustment for disability and cognitive function.


The BDNF val66met polymorphism may modify the association between stroke and depression.

[Indexed for MEDLINE]

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