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Clin Biochem. 2007 Feb;40(3-4):274-7. Epub 2006 Oct 19.

Measurement of lysophospholipase D/autotaxin activity in human serum samples.

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  • 1Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.

Abstract

OBJECTIVES:

Lysophospholipase D (lysoPLD)/autotaxin regulates the blood levels of lysophosphatidic acid (LPA), and we designed a serum lysoPLD assay for use in clinical laboratory testing.

DESIGN AND METHODS:

LysoPLD activity was assessed based on the amount of choline released with lysophosphatidylcholine as the substrate.

RESULTS AND CONCLUSIONS:

It was confirmed that the lysoPLD assay can be applied to clinical laboratory testing. The serum lysoPLD activity in healthy female subjects was significantly higher than that in the male subjects.

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