Format

Send to

Choose Destination
Antimicrob Agents Chemother. 2007 Apr;51(4):1556-8. Epub 2007 Jan 12.

Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters.

Author information

1
Infectious Disease Section, Department of Medicine, Baylor College of Medicine, and Room 4B-370, Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA. saslam@bcm.tmc.edu

Abstract

To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.

PMID:
17220399
PMCID:
PMC1855497
DOI:
10.1128/AAC.00893-06
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center