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Cell Mol Life Sci. 2007 Jan;64(2):117-24.

Telomere attachment and clustering during meiosis.

Author information

1
Inst für Radiobiologie der Bundeswehr, Neuherbergstr 11, D-80937, München, Germany. scherth@web.de

Abstract

Telomeres are important segments of chromosomes that protect chromosome ends from nucleolytic degradation and fusion. At meiosis telomeres display an unprecedented behavior which involves their attachment and motility along the nuclear envelope. The movements become restricted to a limited nuclear sector during the so-called bouquet stage, which is widely conserved among species. Recent observations suggest that telomere clustering involves actin and/or microtubules, and is altered in the presence of impaired recombinogenic and chromosome related functions. This review aims to provide an overview of what is currently known about meiotic telomere attachment, dynamics and regulation in synaptic meiosis.

PMID:
17219025
DOI:
10.1007/s00018-006-6463-2
[Indexed for MEDLINE]

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