Format

Send to

Choose Destination
Mol Cell. 2007 Jan 12;25(1):1-14.

Dynamic regulation of histone lysine methylation by demethylases.

Author information

1
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. yshi@hms.harvard.edu <yshi@hms.harvard.edu>

Abstract

Recent studies demonstrated that histone methylation is not static but is dynamically regulated by histone methyltransferases and the newly discovered histone demethylases. This review discusses the chemical mechanisms for the known and potentially new classes of demethylases, the roles of these demethylases in chromatin and transcription, and their potential biological functions and connections to human diseases.

PMID:
17218267
DOI:
10.1016/j.molcel.2006.12.010
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center