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Cell. 2007 Jan 12;128(1):25-8.

PTEN enters the nuclear age.

Author information

1
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. suzanne.baker@stjude.org

Abstract

Regulation of the PTEN tumor suppressor protein is poorly understood. In this issue, Wang et al. (2007) and Trotman et al. (2007) describe how ubiquitination regulates PTEN stability and its nuclear localization. Additionally, Shen et al. (2007) report that a nuclear pool of PTEN helps to maintain chromosomal stability.

PMID:
17218252
DOI:
10.1016/j.cell.2006.12.023
[Indexed for MEDLINE]
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