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Cell. 2007 Jan 12;128(1):22-3.

A circadian sleep disorder reveals a complex clock.

Author information

1
Howard Hughes Medical Institute, Stanford University School of Medicine, 701-B Welch Road, Stanford, CA 94304, USA. mignot@stanford.edu

Abstract

Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1delta and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length.

PMID:
17218251
PMCID:
PMC3758472
DOI:
10.1016/j.cell.2006.12.024
[Indexed for MEDLINE]
Free PMC Article

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