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Immunol Today. 1991 Sep;12(9):327-31.

Complement evasion strategies of microorganisms.

Author information

1
Dept of Immunology, Scripps Research Institute, La Jolla, CA 92037.

Abstract

The success of microorganisms as human pathogens stems partly from their ability to evade recognition and/or avoid destruction by complement and other natural and acquired defense mechanisms. Here, Neil Cooper reviews the various mechanisms that pathogens have evolved to evade the destructive actions of the complement system, with particular emphasis on the many remarkable examples of the duplication of complement-like structural and functional epitopes by microorganisms. Such mimicry not only enables the pathogens to avoid destruction by complement-mediated mechanisms but also, in a number of instances, facilitates infection.

PMID:
1721820
DOI:
10.1016/0167-5699(91)90010-Q
[Indexed for MEDLINE]

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