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Am J Reprod Immunol. 2007 Feb;57(2):133-41.

Combined thrombophilic mutations in women with unexplained recurrent miscarriage.

Author information

1
Department of Obstetrics and Gynecology, University Hospital of Ioannina, Ioannina, Greece. asotir@gmail.com

Abstract

PROBLEM:

To compare the prevalence of five common thrombophilic polymorphisms and their combination in women with recurrent miscarriage and a control group.

METHOD OF STUDY:

Genomic analysis using polymerase chain reaction (PCR) was carried out in patients with two or more miscarriages and controls for Factor V Leiden, Factor V A1299H (HR2), Factor II G20210A, MTHFR C677T and MTHFR A1298C. Secondary analyses were made for number of miscarriages and gestational age at miscarriage.

RESULTS:

None the mutations was associated with significantly increased risk for recurrent miscarriage. The prevalence of combined thrombophilias (4/88 versus 2/88) did not increase the risk for miscarriage (OR 2.04, 95% CI 0.36-11.47). Although virtually all patients with thrombophilia had miscarriages<or=10 weeks, statistical significance was not reached due to the small size of the >10 weeks' subgroup. There was no difference in the distribution of Factor V Leiden (P=1.000), FII G20210A (P=0.652), and MTHFR C677T (P=0.869) between patients with two and three or more miscarriages, whereas MTHFR A1298C was more common among patients with two miscarriages (P=0.017).

CONCLUSIONS:

Combinations of the five thrombophilic mutations studied are an uncommon event with heterogeneous pattern and they do not significantly increase the risk for miscarriage.

[Indexed for MEDLINE]

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