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Mol Biosyst. 2007 Jan;3(1):18-23. Epub 2006 Nov 22.

Controlling influenza virus replication by inhibiting its proton channel.

Author information

1
Department of Neurobiology and Physiology, Hogan Hall, 2205 Tech Drive, Northwestern University, Evanston, IL 60208-3500, USA. larry-pinto@northwestern.edu

Abstract

Influenza A and viruses encode minimalistic proton-selective ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the antiviral drug, amantadine. The structural and mechanistic aspects of proton conductance of the viral ion channels are described and the review makes a case for the development of more effective antivirals.

PMID:
17216051
DOI:
10.1039/b611613m
[Indexed for MEDLINE]

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