Send to

Choose Destination
Neurology. 2007 Apr 3;68(14):1141-3. Epub 2007 Jan 10.

Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease.

Author information

Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy.


We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center