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J Neurosci. 2007 Jan 10;27(2):304-7.

Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice.

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1
Buck Institute for Age Research, Novato, California 94945, USA.

Abstract

We sought genetic evidence for the involvement of neuronal vascular endothelial growth factor (VEGF) in amyotrophic lateral sclerosis (ALS). Mice expressing human ALS mutant superoxide dismutase-1 (SOD1) were crossed with mice that overexpress VEGF in neurons (VEGF+/+). We report that SOD1(G93A)/VEGF+/+ double-transgenic mice show delayed motor neuron loss, delayed motor impairment, and prolonged survival compared with SOD1(G93A) single transgenics. These findings indicate that neuronal VEGF protects against motor neuron degeneration, and may have therapeutic implications for ALS.

PMID:
17215390
PMCID:
PMC2830908
DOI:
10.1523/JNEUROSCI.4433-06.2007
[Indexed for MEDLINE]
Free PMC Article
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