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Semin Cell Dev Biol. 2006 Dec;17(6):630-7. Epub 2006 Dec 1.

Regulation of TRP channels by N-linked glycosylation.

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Division of Nephrology and Hypertension, Department of Medicine, Oregon Health & Science University, Portland Veterans Affairs Medical Center, Portland, OR 97239, USA.


A subset of TRP channel proteins undergoes regulatory N-linked glycosylation. A glycosylation site in the first extracellular loop of TRPV5 is enzymatically cleaved by a secreted glucuronidase, indirectly regulating channel function. Members of the TRPC family share a similar site, although details about a regulatory role are lacking. A second conserved TRP channel glycosylation site is found immediately adjacent to the channel pore-forming loop; both TRPV1 and TRPV4--and perhaps other TRPV family members--are influenced by glycosylation at this site. N-linked glycosylation, and the dynamic regulation of this process, substantially impacts function and targeting of TRP channels.

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