Format

Send to

Choose Destination
Biosci Biotechnol Biochem. 2007 Jan;71(1):242-5. Epub 2007 Jan 7.

Human MDR1 and MRP1 recognize berberine as their transport substrate.

Author information

1
Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Japan.

Abstract

To examine whether human ATP-binding cassette (ABC) transporters play a role in the detoxification of plant alkaloid berberine, we investigated berberine transport using multidrug resistance protein1 (MDR1) and multidrug resistance-associated protein1 (MRP1). Cells expressing MDR1 or MRP1 accumulated less berberine. Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate.

PMID:
17213652
DOI:
10.1271/bbb.60441
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center