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Biosci Biotechnol Biochem. 2007 Jan;71(1):234-7. Epub 2007 Jan 7.

A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis.

Author information

1
Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan.

Abstract

In the large-intestinal mucosae of rats orally administered dextran sulfate sodium, which induces an enteritis resembling ulcerative colitis (UC), the activity for granzyme A, a lymphocyte tryptase, increased at an earlier stage than that at which UC markers (growth-regulated gene product/cytokine-induced neutrophil chemoattractant-1 and caspase-3) increased. This suggests involvement of the enzyme in the exacerbation and perpetuation of enteritis.

PMID:
17213646
DOI:
10.1271/bbb.60354
[Indexed for MEDLINE]
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