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J Clin Pathol. 2007 Jan;60(1):82-4.

Infiltrating giant cellular blue naevus.

Author information

1
Department of Pathology, Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil. achilea@uol.com.br

Abstract

INTRODUCTION:

Cellular blue naevi (CBN) measure 1-2 cm in diameter and affect the dermis, occasionally extending into the subcutaneous fat. The case of a 14-year-old boy with a giant CBN (GCBN) involving the right half of the face, the jugal mucosa and the lower eyelid with a tumour that had infiltrated the bone and the maxillary and ethmoidal sinuses is reported.

METHODS:

Biopsies were taken from the skin, jugal mucosa and maxillary sinus. The following markers were used in the immunohistochemical evaluation: CD34, CD56, HMB-45, anti-S100, A-103, Melan A and MIB-1.

RESULTS:

The biopsy specimens showed a biphasic pattern affecting the lower dermis, subcutaneous fat, skeletal muscle, bone, jugal mucosa and maxillary sinus, but there was no histological evidence of malignancy. The tumour cells were CD34-, CD56-, HMB45+, anti-S100+ and A-103+. Melan A was focally expressed. No positive MIB-1 cells were identified.

DISCUSSION:

The present case shows that GCBN may infiltrate deeply, with no evidence of malignancy.

PMID:
17213350
PMCID:
PMC1860607
DOI:
10.1136/jcp.2005.029488
[Indexed for MEDLINE]
Free PMC Article

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