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Trends Cardiovasc Med. 2007 Jan;17(1):26-30.

Smoothelin in vascular smooth muscle cells.

Author information

  • 1Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands. g.vaneys@gen.unimaas.nl

Abstract

Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells. They are increasingly used to monitor the smooth muscle cell differentiation process to a contractile or synthetic phenotype. Vascular-specific smoothelin-B is the first smooth muscle cell marker that disappears when vascular tissues are compromised, for example, in atherosclerosis or restenosis. Recently obtained data show that smoothelin deficiency results in a considerable loss of contractile potential and hence in impaired smooth muscle function and suggest that smoothelins are part of the contractile apparatus.

PMID:
17210475
DOI:
10.1016/j.tcm.2006.11.001
[PubMed - indexed for MEDLINE]
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