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Otolaryngol Head Neck Surg. 2007 Jan;136(1):112-8.

Impact of recurrence interval on survival of oral cavity squamous cell carcinoma patients after local relapse.

Author information

1
Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.

Abstract

OBJECTIVE:

The aim of this study was to investigate whether the recurrence interval influenced the survival of oral cavity squamous cell carcinoma patients after relapse.

STUDY DESIGN AND SETTING:

Retrospective charts were reviewed at a medical center.

METHODS:

We retrospectively reviewed 1687 chart records of oral cancer patients. Statistical methods included descriptive statistics, bivariate analyses, Kaplan-Meier survival analyses, and Cox proportional hazard models for investigating the relationship between the recurrence interval and survival of oral cancer patients after relapse.

RESULTS:

Local recurrence rate was 31.3 percent. Kaplan-Meier survival analyses showed the 5-year overall survival after recurrence was 31.56 percent. Cox proportional hazard model revealed that those with recurrence interval less than 18 months tended to have a higher probability of death than those with recurrence interval greater than or equal to 18 months (relative risk, 1.743; 95% confidence interval, 1.298-2.358).

CONCLUSION:

The interval from initial treatment to recurrence is an independent prognostic factor for oral squamous cell carcinoma patients. Those with a shorter disease-free interval tend to have a less favorable outcome.

PMID:
17210345
DOI:
10.1016/j.otohns.2006.07.002
[Indexed for MEDLINE]

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