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Otolaryngol Head Neck Surg. 2007 Jan;136(1):72-7.

A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium.

Author information

1
Department of Otorhinolaryngology, Charité-University Medicine Berlin, Berlin, Germany.

Abstract

OBJECTIVE:

To determine the short-term effects of coenzyme Q10 (CoQ10) on the antioxidative status and tinnitus expression in patients with chronic tinnitus aurium.

STUDY DESIGN:

A 16-week prospective nonrandomized clinical trial (n = 20). Tinnitus and Short Form-36 Questionnaires (TQ/SF-36) were evaluated together with the plasma concentrations of CoQ10, malondialdehyde, and the total antioxidant status.

RESULTS:

The mean plasma CoQ10 concentration rose under external CoQ10 supply and remained elevated after medication stopped without overall effects on the tinnitus score. However, in a subgroup of 7 patients with low initial plasma CoQ10 concentration and significant increase in the plasma CoQ10 level, a clear decrease in the TQ score was observed.

CONCLUSION:

In patients with a low plasma CoQ10 concentration, CoQ10 supply may decrease the tinnitus expression.

SIGNIFICANCE:

This is the first study to examine the effect of CoQ10 in chronic tinnitus aurium.

PMID:
17210337
DOI:
10.1016/j.otohns.2006.07.010
[Indexed for MEDLINE]

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