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Fertil Steril. 2007 May;87(5):1213.e1-3. Epub 2007 Jan 17.

Supernumerary minute ring chromosome 14 in a man with primary infertility and left varicocele.

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1
Department of Urology, University of Iowa, Iowa City, Iowa 52242-1089, USA.

Abstract

OBJECTIVE:

To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele.

DESIGN:

Case report.

SETTING:

Urologic infertility clinic in a university hospital.

PATIENT(S):

Male patient presenting with primary infertility.

INTERVENTION(S):

Karyotyping, genetic counseling, and microsurgical left varicocelectomy.

MAIN OUTCOME MEASURE(S):

Sperm concentration and motility, chromosomal number and structure.

RESULT(S):

Fluorescence in situ hybridization revealing SMRC 14. Sperm concentration and motility improved after left varicocele repair.

CONCLUSION(S):

A karyotype should be included in the evaluation of severe oligospermia. Although SMRC 14 may be associated with fertility problems, repair of a coexisting varicocele should be considered in these patients.

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