Send to

Choose Destination
See comment in PubMed Commons below
J Pharm Biomed Anal. 2007 Apr 11;43(5):1615-21. Epub 2007 Jan 4.

Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement.

Author information

  • 1US Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA.


A new analogue of sildenafil was detected in an herbal dietary supplement, which was sold over the internet and promoted as a product for the enhancement of sexual performance. The structure of the compound was established using LC-MS, UV spectroscopy, MS-MS, and NMR. In addition, the compound was cleaved at its sulfonamide S-N bond yielding a sulfonic acid and an amine, which were independently characterized using LC-MS, GC-MS, and derivatization. The compound, named methisosildenafil, is a novel synthetic analogue of sildenafil in which the N-methylpiperazine moiety has been replaced with 2,6-dimethylpiperazine.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center