Format

Send to

Choose Destination
Transfusion. 2007 Jan;47(1):55-8.

Maternal human platelet antigen-1a antibody level correlates with the platelet count in the newborns: a retrospective study.

Author information

1
Department of Immunology and Transfusion Medicine, University Hospital of North Norway, Norway. mette.kjaer.killie@unn.no

Abstract

BACKGROUND:

Maternal plasma and/or serum levels of anti-HPA-1a at delivery were compared to neonatal platelet (PLT) counts.

STUDY DESIGN AND METHODS:

Samples from HPA-1bb women who gave birth to children with thrombocytopenia or had anamnestic information about a previous child with neonatal alloimmune thrombocytopenia (NAIT) were collected at delivery. A modified monoclonal antibody immobilization of PLT antigen method was used for quantification of anti-HPA-1a.

RESULTS:

The anti-HPA-1a level in women with severely thrombocytopenic children was higher than the corresponding level in mothers of children born with moderate thrombocytopenia or normal PLT counts.

CONCLUSION:

Our data show a significant correlation between maternal anti-HPA-1a level and the neonatal PLT count and indicate strongly that this may be a reliable predictive measure for NAIT. Suitable test systems for quantitative measurements of anti-HPA-1a must be developed and evaluated for this particular purpose.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center