Send to

Choose Destination
See comment in PubMed Commons below
World J Gastroenterol. 2007 Jan 7;13(1):91-103.

Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism.

Author information

  • 1Department of General Virology, Heinrich-Pette-Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, PO Box 201652, Hamburg 20206, Germany.


The human hepatitis B virus (HBV) and the duck hepatitis B virus (DHBV) share several fundamental features. Both viruses have a partially double-stranded DNA genome that is replicated via a RNA intermediate and the coding open reading frames (ORFs) overlap extensively. In addition, the genomic and structural organization, as well as replication and biological characteristics, are very similar in both viruses. Most of the key features of hepadnaviral infection were first discovered in the DHBV model system and subsequently confirmed for HBV. There are, however, several differences between human HBV and DHBV. This review will focus on the molecular and cellular biology, evolution, and host adaptation of the avian hepatitis B viruses with particular emphasis on DHBV as a model system.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
    Loading ...
    Support Center