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Nat Med. 2007 Feb;13(2):147-9. Epub 2007 Jan 7.

Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract.

Author information

1
Department of Pathology, University of Hong Kong, Pok Fu Lam Road, Hong Kong SAR, China. nicholls@pathology.hku.hk

Abstract

Poor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid alpha2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors.

PMID:
17206149
DOI:
10.1038/nm1529
[Indexed for MEDLINE]

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