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J Proteome Res. 2007 Jan;6(1):89-96.

Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection.

Author information

1
Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA. gravettm@u.washington.edu

Abstract

Intra-amniotic infection (IAI) is associated with preterm birth and perinatal mortality. To identify potential biomarkers, we performed a comprehensive survey of the cervical-vaginal fluid (CVF) proteome from a primate IAI model utilizing multidimensional protein identification technology (LC/LC-MS/MS) and MALDI-TOF-MS analyses. Analyses of CVF proteome identified 205 unique proteins and differential expression of 27 proteins in controls and IAI samples. Protein expression signatures and immunodetection of specific biomarkers identified can be employed for noninvasive detection of IAI.

PMID:
17203952
PMCID:
PMC2532920
DOI:
10.1021/pr060149v
[Indexed for MEDLINE]
Free PMC Article

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