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J Neuroimmunol. 1991 Dec;35(1-3):227-36.

Autoantigen-induced self lysis of human myelin basic protein-specific T lymphocytes.

Author information

1
V.A. Medical Center, Neurovirology Research, University of Utah School of Medicine, Salt Lake City.

Abstract

Cytotoxic T cells reactive with myelin basic protein (MBP) may be isolated from most human subjects. Since activated T cells express major histocompatibility complex (MHC) class II antigens, we assessed whether MBP-specific, CD4+ T cells could present MBP or synthetic MBP peptides to themselves and whether this provoked self lysis. We examined two MBP-specific cell lines and eight T cell clones recognizing four different MBP epitopes. All T cell populations presented MBP as well as synthetic peptides to themselves eliciting self lysis of the T cell clones. CD4+ T cell populations recognizing another central nervous system (CNS) protein, proteolipid protein (PLP), or the recall antigen, Candida, did not exhibit this antigen-induced, autocytolytic activity. However, activated, PLP-reactive T cells were susceptible to lysis by cytotoxic MBP-specific T cells in the presence of MBP. These results suggest that antigen-induced self lysis of activated human T cells might limit an autoimmune response within a target organ independent of other immunoregulatory mechanisms.

PMID:
1720135
DOI:
10.1016/0165-5728(91)90177-9
[Indexed for MEDLINE]

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