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Trends Immunol. 2007 Feb;28(2):45-7. Epub 2007 Jan 2.

Outside looking in: the inner workings of the cross-presentation pathway within dendritic cells.

Author information

1
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia.

Abstract

The entry of exogenous antigen into the MHC class I-restricted cross-presentation pathway can contribute to CD8(+) T cell tolerance and immunity, in particular to peripheral self-antigens or selected viruses and bacteria showing restricted tissue tropism. Dendritic cells are the key cross-presenting cells and, as such, they are thought to carry specialized machinery dedicated to this purpose. Two recent papers describe intracellular components tailored to the dendritic cell cross-presentation pathway.

PMID:
17197240
DOI:
10.1016/j.it.2006.12.008
[Indexed for MEDLINE]

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