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Arch Biochem Biophys. 2007 Mar 1;459(1):27-32. Epub 2006 Dec 3.

Sphingomyelin-cholesterol and double stranded RNA relationship in the intranuclear complex.

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Department of Clinical and Experimental Medicine, Physiopathology, University School of Medicine, Policlinico Monteluce, via Brunamonti, 06100 Perugia, Italy.


The nuclear double-stranded RNA can be exported to the cytoplasm leading to the incorporation alternative aminoacids into the translated protein, can be retained to the nucleus playing a role on quality control nuclear function or can engaged by vigilin complex initiating the heterochromatin function. In the nucleus this RNA is associated to the protein, a small amount of DNA, sphingomyelin, phosphatidylcholine, and enzymes related to sphingomyelin metabolism such as sphingomyelinase and sphingomyelin-synthase constituting an intranuclear complex. Our data show an association between cholesterol and sphingomyelin that could play a role in double strand formation after RNA synthesis since [3H]-uridine incorporation demonstrates that nuclear double stranded RNA is new-synthesized. The presence of the lamin B as a protein of the intranuclear complex suggests that it could correspond to the transcription sites associated to the inner nuclear membrane.

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