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Neuron. 2007 Jan 4;53(1):39-52.

C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli.

Author information

1
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

Abstract

Signal transduction through heterotrimeric G proteins is critical for sensory response across species. Regulator of G protein signaling (RGS) proteins are negative regulators of signal transduction. Herein we describe a role for C. elegans RGS-3 in the regulation of sensory behaviors. rgs-3 mutant animals fail to respond to intense sensory stimuli but respond normally to low concentrations of specific odorants. We find that loss of RGS-3 leads to aberrantly increased G protein-coupled calcium signaling but decreased synaptic output, ultimately leading to behavioral defects. Thus, rgs-3 responses are restored by decreasing G protein-coupled signal transduction, either genetically or by exogenous dopamine, by expressing a calcium-binding protein to buffer calcium levels in sensory neurons or by enhancing glutamatergic synaptic transmission from sensory neurons. Therefore, while RGS proteins generally act to downregulate signaling, loss of a specific RGS protein in sensory neurons can lead to defective responses to external stimuli.

PMID:
17196529
PMCID:
PMC1855255
DOI:
10.1016/j.neuron.2006.11.015
[Indexed for MEDLINE]
Free PMC Article

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