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Neuron. 2007 Jan 4;53(1):1-4.

High affinity not in the vicinity?

Author information

1
Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada. phil.barker@mcgill.ca

Abstract

Functional interactions between the p75 neurotrophin receptor (p75NTR) and the Trk receptors were demonstrated several years ago, but their mechanistic basis remains uncertain. In this issue of Neuron, Wehrman et al. provide a three-dimensional structure of the full TrkA ectodomain complexed to NGF and examine the possibility of a ternary p75NTR-NGF-TrkA complex.

PMID:
17196523
DOI:
10.1016/j.neuron.2006.12.018
[Indexed for MEDLINE]
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