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Stroke. 2007 Feb;38(2):398-401. Epub 2006 Dec 28.

Is diabetic retinopathy an independent risk factor for ischemic stroke?

Author information

1
Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia.

Abstract

BACKGROUND AND PURPOSE:

The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study.

METHODS:

A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated.

RESULTS:

Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86).

CONCLUSIONS:

Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors.

[Indexed for MEDLINE]

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