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Am J Geriatr Psychiatry. 2007 Jan;15(1):84-7.

Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia.

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  • 1Department of Neurology, University of California at Los Angeles, Los Angeles, CA, USA.



The objective of this study was to evaluate donepezil, an acetylcholinesterase inhibitor, in the treatment of frontotemporal dementia (FTD).


Twelve patients with FTD who received donepezil for six months were compared with 12 FTD controls on behavioral measures.


The groups did not differ on most variables at baseline or at six months; however, the donepezil group had greater worsening on the FTD Inventory. Four treated patients had increased disinhibited or compulsive acts, which abated with discontinuation of the medication.


There were no changes in global cognitive performance or dementia severity; however, a subgroup of patients with FTD can experience worsening of symptoms with donepezil.

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