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Mol Cell Biol. 2007 Mar;27(5):1859-67. Epub 2006 Dec 28.

A microRNA signature of hypoxia.

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  • 1Molecular Oncology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.

Abstract

Recent research has identified critical roles for microRNAs in a large number of cellular processes, including tumorigenic transformation. While significant progress has been made towards understanding the mechanisms of gene regulation by microRNAs, much less is known about factors affecting the expression of these noncoding transcripts. Here, we demonstrate for the first time a functional link between hypoxia, a well-documented tumor microenvironment factor, and microRNA expression. Microarray-based expression profiles revealed that a specific spectrum of microRNAs (including miR-23, -24, -26, -27, -103, -107, -181, -210, and -213) is induced in response to low oxygen, at least some via a hypoxia-inducible-factor-dependent mechanism. Select members of this group (miR-26, -107, and -210) decrease proapoptotic signaling in a hypoxic environment, suggesting an impact of these transcripts on tumor formation. Interestingly, the vast majority of hypoxia-induced microRNAs are also overexpressed in a variety of human tumors.

PMID:
17194750
PMCID:
PMC1820461
DOI:
10.1128/MCB.01395-06
[PubMed - indexed for MEDLINE]
Free PMC Article
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