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Bioorg Med Chem Lett. 2007 Mar 1;17(5):1392-8. Epub 2006 Dec 3.

A potent and orally active HIV-1 integrase inhibitor.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. melissa_egbertson@merck.com

Abstract

A 1,6-naphthyridine inhibitor of HIV-1 integrase has been discovered with excellent inhibitory activity in cells, good pharmacokinetics, and an excellent ability to inhibit virus with mutant enzyme.

PMID:
17194584
DOI:
10.1016/j.bmcl.2006.11.080
[Indexed for MEDLINE]

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