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Neurosci Lett. 1991 Jul 22;128(2):281-4.

Serotonin hyperinnervation after foetal nigra or raphe transplantation in the neostriatum of adult rats.

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  • 1Department of Preclinical Veterinary Sciences, University of Edinburgh, U.K.


Embryonic nigral or raphé grafts implanted in the dopamine-depleted neostriatum contain serotonergic neurones and give rise to a serotonergic hyperinnervation of the host striatum. No similar pattern of hyperinnervation is observed in rats with striatal tissue grafts, rats with nigral grafts implanted in the intact striatum, or rats with lesions alone. These observations suggest that striatal dopamine denervation induces some target-derived trophic factors that stimulate fibre growth from serotonergic as well as dopaminergic neurones.

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