Format

Send to

Choose Destination
Biochim Biophys Acta. 2007 Aug;1773(8):1248-55. Epub 2006 Nov 16.

Clinical experience of MEK inhibitors in cancer therapy.

Author information

1
Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University, 4th Floor HWCRC, 4100 John R, Detroit, MI 48201, USA.

Abstract

Finding new therapies to assist in the treatment of cancer is a major challenge of clinical research. Small molecules that inhibit different molecular targets at the different levels of the MAPK pathway have been developed. Several MEK inhibitors have been examined in early-phase clinical trials and the current state of clinical results using these therapies is presented here.

PMID:
17194493
DOI:
10.1016/j.bbamcr.2006.11.009
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center