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Bioorg Med Chem Lett. 2007 Mar 1;17(5):1226-32. Epub 2006 Dec 12.

Simple criterion for selection of flavonoid compounds with anti-HIV activity.

Author information

1
Centre for Multidisciplinary Research, Institute of Nuclear Sciences VINCA, PO Box 522, 11001 Belgrade, Serbia. vv@vin.bg.ac.yu

Abstract

Flavonoid compounds represent an important natural source of antiretrovirals for AIDS therapy due to their significant anti-HIV-1 activity and low toxicity. Here we propose a simple theoretical criterion to discriminate active from inactive flavonoids that is suitable for rapid in silico screening of flavonoid libraries, and selection and optimization of lead compounds with anti-HIV-1 activity.

PMID:
17189684
DOI:
10.1016/j.bmcl.2006.12.029
[Indexed for MEDLINE]

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