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Cell Metab. 2007 Jan;5(1):7-8.

Angiotensin in the kidney: a key to understanding hypertension?

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1
Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany.

Abstract

A crosstransplantation study between genetically matched angiotensin AT1 receptor knockout and wild-type mice revealed that renal AT1 receptors are required for the development of angiotensin II-induced hypertension (). However, in this experimental setting, hypertension-related left ventricular hypertrophy seemed to depend on blood pressure elevation rather than on the expression of AT1 receptors in the heart.

PMID:
17189202
DOI:
10.1016/j.cmet.2006.12.007
[Indexed for MEDLINE]
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