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Bioorg Med Chem Lett. 2007 Feb 15;17(4):925-31. Epub 2006 Nov 22.

1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists.

Author information

1
Process Chemistry Laboratories, Pharmaceutical Technology Center, Mitsubishi Pharma Corporation, 14, Sunayama, Kamisu, Ibaraki 314-0255, Japan. Sonda.Shuuji@ma.m-pharma.co.jp

Abstract

The structure-activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M(1)-M(3) receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M(3) receptor and potent effect on rhythmic increase in bladder pressure in unanesthetized rats following oral administration. These compounds displayed selectivity for the bladder over the salivary gland.

PMID:
17188867
DOI:
10.1016/j.bmcl.2006.11.058
[Indexed for MEDLINE]

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