Format

Send to

Choose Destination
Am J Ophthalmol. 2007 Jan;143(1):173-4. Epub 2006 Aug 31.

Dronabinol and retinal hemodynamics in humans.

Author information

1
Department of Ophthalmology, RWTH Aachen University, Pauwelstrasse 30, 52057 Aachen, Germany. nplange@ukaachen.de

Abstract

PURPOSE:

To investigate the effects of oral cannabinoids on retinal hemodynamics assessed by video fluorescein angiography in healthy subjects.

DESIGN:

Interventional study.

METHODS:

In a self-experiment, the cannabinoid dronabinol (delta-9-tetrahydrocannabinol [THC]) was administered orally to eight healthy medical doctors (7.5 mg Marinol; Unimed Pharmaceuticals, Chicago, Illinois, USA). At baseline and two hours after dronabinol intake, intraocular pressure (IOP) was measured and retinal hemodynamics were assessed by fluorescein angiography. The retinal arteriovenous passage time was determined on the basis of dye dilution curves by means of digital image analysis in a masked fashion.

RESULTS:

Dronabinol resulted in a significant IOP reduction from 13.2 +/- 1.9 mm Hg to 11.8 +/- 2.0 mm Hg (P = .038). The retinal arteriovenous passage time decreased from 1.77 +/- 0.35 seconds to 1.57 +/- 0.31 seconds (P = .028). Systemic blood pressure and heart rate were not statistically significantly altered.

CONCLUSIONS:

Cannabinoids, already known for their ability to reduce IOP, may result in increased retinal hemodynamics. This may be beneficial in ocular circulatory disorders, including glaucoma.

PMID:
17188063
DOI:
10.1016/j.ajo.2006.07.053
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center